Cysteine residues of the porcine reproductive and respiratory syndrome virus ORF5a protein are not essential for virus viability
ORF5a protein was recently identified as a novel structural protein in porcine reproductive
and respiratory syndrome virus (PRRSV). The ORF5a protein possesses two cysteines at
positions 29 and 30 that are highly conserved among type 2 PRRSV. In this study, the
significance of the ORF5a protein cysteine residues on virus replication was determined
based on a type 2 PRRSV cDNA clone (pAJXM). Each cysteine was substituted by serine or
glycine and the mutations were introduced into pAJXM. We found that the replacement of …
and respiratory syndrome virus (PRRSV). The ORF5a protein possesses two cysteines at
positions 29 and 30 that are highly conserved among type 2 PRRSV. In this study, the
significance of the ORF5a protein cysteine residues on virus replication was determined
based on a type 2 PRRSV cDNA clone (pAJXM). Each cysteine was substituted by serine or
glycine and the mutations were introduced into pAJXM. We found that the replacement of …
Cysteine residues of the porcine reproductive and respiratory syndrome virus ORF5a protein are not essential for virus viability.
SLC Sun LiChang, ZY Zhou Yan, LRX Liu RunXia… - 2015 - cabidigitallibrary.org
ORF5a protein was recently identified as a novel structural protein in porcine reproductive
and respiratory syndrome virus (PRRSV). The ORF5a protein possesses two cysteines at
positions 29 and 30 that are highly conserved among type 2 PRRSV. In this study, the
significance of the ORF5a protein cysteine residues on virus replication was determined
based on a type 2 PRRSV cDNA clone (pAJXM). Each cysteine was substituted by serine or
glycine and the mutations were introduced into pAJXM. We found that the replacement of …
and respiratory syndrome virus (PRRSV). The ORF5a protein possesses two cysteines at
positions 29 and 30 that are highly conserved among type 2 PRRSV. In this study, the
significance of the ORF5a protein cysteine residues on virus replication was determined
based on a type 2 PRRSV cDNA clone (pAJXM). Each cysteine was substituted by serine or
glycine and the mutations were introduced into pAJXM. We found that the replacement of …
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