[HTML][HTML] Cytokine profiles during carrageenan-induced inflammatory hyperalgesia in rat muscle and hind paw

LC Loram, A Fuller, LG Fick, T Cartmell, S Poole… - The Journal of …, 2007 - Elsevier
It is not known if a cytokine cascade develops during muscle inflammation and whether
cytokines contribute to muscle inflammatory pain. We measured plasma and tissue cytokine
concentrations, and behavioral responses to noxious mechanical stimuli, after inducing
inflammation in the gastrocnemius muscle and the hind paw of rats. Tissue and plasma
samples were taken 3, 6, or 24 h after carrageenan or saline injection into one of the 2 sites.
Tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, and cytokine-induced …
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