We hypoihesize that cell-cell communication disturbance is an-important patho genetic mechanism in all steps of atherogenesis. The pathogenesis. in most patholog ic processes may be considered from a new point of view: as the result of disturbances of “habitual” сеЦ-сеП communications? These “habijpal” communica tions are made possible by four classes of mediators (messengers): cell adhesion molecules, extracellular matrix, cytokines, and protooncogens. 2 The main goal of our research was the comparative analysis of cytokines, soluble cell adhesion molecule (sCAM) secretion after blood coagulation and high shear rate for studying the involvement of hemostasis in pathophysiology of atherosclerosis.