Context: Cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) polymorphisms have been
widely examined for their associations with autoimmune thyroid diseases [Graves' disease
(GD) and Hashimoto thyroiditis (HT)], but their relative population effect remains unclear.
Objective: The aim was to generate large-scale evidence on whether the CTLA-4
polymorphisms (A49G and CT60) and haplotypes thereof increase the susceptibility to GD
and/or HT. Design, Setting, and Participants: Meta-analyses of group-level data were …

The association of the cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4) gene and
susceptibility to autoimmune thyroid diseases (AITDs) has been studied extensively.
However, the results were not the same in different ethnic groups. We updated the meta‐
analysis of association of CTLA‐4 gene polymorphisms with AITDs and summarized the
results in specific ethnicity. The associations of A49G gene polymorphism with GD, A49G
gene polymorphism with HT, CT60 gene polymorphism with GD, and CT60 gene …