… of plasma and DBS in the clinical setting. In view of the above, the aim of this study is to
develop and evaluate the clinical application of a DBS sampling method for the measurement of …

… for imatinib and 10–1500 ng/mL for norimatinib. Analytes were extracted from DBS samples
by … Therapeutic drug monitoring supported by liquid chromatography coupled with tandem …

… of the extraction procedure during method development is critical to ensure … DBS samples
and DBS samples generated by pipetting venous blood on the card, as exemplified for imatinib …

… developed a LC-MS/MS method for the quantification of imatinib in finger-prick DBS samples
… (66): they demonstrated a significant partition of imatinib into blood cells and measured an …

… DBS sampling for the TDM of chemotherapy and targeted … Of these studies, 20 described
analytical method development, … and precision of the developed methods (imatinib). The …

… for sample purification during method development were … concentration of imatinib from the
corresponding C DBS using the … and the type of DBS card or analytical method used has not …

… Analytes were extracted from DBS samples by simply adding … imatinib is N-desmethyl imatinib,
also known as nor-imatinib (… of a particular method developed for the quantification of an …

… also be performed in therapeutic drug monitoring of TKIs. The present article describes …
method developed was used to analyse 24 CML patient DBS samples on therapy with imatinib (…

… Therapeutic drug monitoring should be routinely … a DBS is affected by HCT, which may
result in an underestimation of concentration in low HCT and overestimation in high HCT samples…

… in therapeutic drug monitoring approaches, especially for … anticancer drugs belonging to
the kinase inhibitors (imatinib, … on the key parameters for DBS method development; (c) to …