[HTML][HTML] DEP-induced ZEB2 promotes nasal polyp formation via epithelial-to-mesenchymal transition

M Lee, S Lim, YS Kim, R Khalmuratova, SH Shin… - Journal of Allergy and …, 2022 - Elsevier
Background Diesel exhaust particles (DEPs) are associated with the prevalence and
exacerbation of allergic respiratory diseases, including allergic rhinitis and allergic asthma.
However, DEP-induced mechanistic pathways promoting upper airway disease and their
clinical implications remain unclear. Objective We sought to investigate the mechanisms by
which DEP exposure contributes to nasal polyposis using human-derived epithelial cells
and a murine nasal polyp (NP) model. Methods Gene set enrichment and weighted gene …
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