DJ-1, a novel regulator of the tumor suppressor PTEN
RH Kim, M Peters, YJ Jang, W Shi, M Pintilie… - Cancer cell, 2005 - cell.com
Summary The phosphatidylinositol 3′ kinase (PI3′ K) pathway, which regulates cell
survival, is antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear. A
genetic screen of Drosophila gain-of-function mutants identified DJ-1 as a suppressor of
PTEN function. In mammalian cells, DJ-1 underexpression results in decreased
phosphorylation of PKB/Akt, while DJ-1 overexpression leads to hyperphosphorylation of
PKB/Akt and increased cell survival. In primary breast cancer samples, DJ-1 expression …
survival, is antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear. A
genetic screen of Drosophila gain-of-function mutants identified DJ-1 as a suppressor of
PTEN function. In mammalian cells, DJ-1 underexpression results in decreased
phosphorylation of PKB/Akt, while DJ-1 overexpression leads to hyperphosphorylation of
PKB/Akt and increased cell survival. In primary breast cancer samples, DJ-1 expression …
[引用][C] DJ-1, a novel regulator of the tumor suppressor PTEN
KIM RH - Cancer Cell, 2005 - cir.nii.ac.jp
DJ-1, a novel regulator of the tumor suppressor PTEN | CiNii Research … CiNii Books …
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