… IgG DNA-reactive antibodies originate when B cell tolerance … activation of DNA-reactive B
cells in various B cell subsets at … for lupus and their effect on tolerance of DNA-reactive B cells …

… Our goal in this study was to test whether we could identify autoreactive B cells reactive to
peptide and dsDNA in lupus patients by virtue of their binding to fluorochome-tagged tetramer. …

… These results suggest that mutated IgM anti-dsDNA antibodies may develop from both DNA-
and non-DNA-reactive B cells. The implications are that B cell activation occurs in response …

… , a molecule found in various membranes, was shown to induce generation, through
somatic mutation, of DNA-reactive B cells, although these cells never move to the memory …

… B cells are thought to be disturbed in patients with SLE. The characterization of DNA-reactive
B cells … , we can identify B cells producing potentially pathogenic DNA-reactive antibodies. …

… B cells is greatly enhanced by the MRL/lpr lupus-prone genetic background. Sle2 also enhances
the activation and differentiation of 56R Tg autoreactive B cells; in these cells… Tg B cells …

… Finally, because BCR-mediated uptake of CpG-DNA is much more efficient than passive
uptake, DNA-reactive B cells should have much higher intracellular concentrations of CpG-DNA…

… proliferation of B cells, including DNA reactive B cells in SLE, RA (… as a direct autoantigen for
DNA-reactive B cells. Further … effect of IFNα on B cells in various lupus-prone mouse models …

… frequencies of DNA-reactive B cells entering the memory B cell pool from the naive B cell
compartment in SLE patients but increased numbers of DNA-reactive memory B cells in …

… (59) maintained that studying genetic risk alleles can improve our understanding of failed
tolerance mechanisms for DNA-reactive B cells and B cell alterations in SLE. Understanding …