Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells
M Momeny, G Zarrinrad, F Moghaddaskho… - Scientific Reports, 2017 - nature.com
Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy worldwide.
Development of chemoresistance and peritoneal dissemination of EOC cells are the major
reasons for low survival rate. Targeting signal transduction pathways which promote therapy
resistance and metastatic dissemination is the key to successful treatment. Members of the
ErbB family of receptors are over-expressed in EOC and play key roles in chemoresistance
and invasiveness. Despite this, single-targeted ErbB inhibitors have demonstrated limited …
Development of chemoresistance and peritoneal dissemination of EOC cells are the major
reasons for low survival rate. Targeting signal transduction pathways which promote therapy
resistance and metastatic dissemination is the key to successful treatment. Members of the
ErbB family of receptors are over-expressed in EOC and play key roles in chemoresistance
and invasiveness. Despite this, single-targeted ErbB inhibitors have demonstrated limited …
Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells
R Ghasemi - 2017 - digitalcommons.wustl.edu
Results Chemosensitivity of the EOC cell lines. The chemoresponsiveness of a panel of
EOC cell lines to certain chemotherapeutics and targeted therapies were determined by
MTT assay and are summarized in Table 1. These data show that OVCAR3, SKOV3 and
A2780CP cells exhibit resistance to carboplatin, doxorubicin and cetuximab, as compared to
A2780S and Caov4 cells (Table 1; Supplementary Fig. 1).
EOC cell lines to certain chemotherapeutics and targeted therapies were determined by
MTT assay and are summarized in Table 1. These data show that OVCAR3, SKOV3 and
A2780CP cells exhibit resistance to carboplatin, doxorubicin and cetuximab, as compared to
A2780S and Caov4 cells (Table 1; Supplementary Fig. 1).