[HTML][HTML] Dangerous liaisons: how the immune system deals with factor VIII
A Wroblewska, BM Reipert, KP Pratt… - Journal of Thrombosis and …, 2013 - Elsevier
Only a fraction of patients with hemophilia A develop a neutralizing antibody (inhibitor)
response to therapeutic infusions of factor VIII. Our present understanding of the underlying
causes of the immunogenicity of this protein is limited. In the past few years, insights into the
uptake and processing of FVIII by antigen‐presenting cells (APCs) have expanded
significantly. Although the mechanism of endocytosis remains unclear, current data indicate
that FVIII enters APCs via its C1 domain. Its subsequent processing within endolysosomes …
response to therapeutic infusions of factor VIII. Our present understanding of the underlying
causes of the immunogenicity of this protein is limited. In the past few years, insights into the
uptake and processing of FVIII by antigen‐presenting cells (APCs) have expanded
significantly. Although the mechanism of endocytosis remains unclear, current data indicate
that FVIII enters APCs via its C1 domain. Its subsequent processing within endolysosomes …
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