Deciphering transcriptional and functional heterogeneity in hematopoiesis with single-cell genomics
JD Martin-Rufino, VG Sankaran - Current opinion in hematology, 2021 - journals.lww.com
Current opinion in hematology, 2021•journals.lww.com
An understanding of the limitations of single-cell genomic approaches and follow-up
functional assays is critical to discern the technical and biological contribution of noise in
hematopoietic heterogeneity, to identify rare gene expression states, and to uncover
functionally distinct subpopulations within hematopoiesis.
functional assays is critical to discern the technical and biological contribution of noise in
hematopoietic heterogeneity, to identify rare gene expression states, and to uncover
functionally distinct subpopulations within hematopoiesis.
Summary
An understanding of the limitations of single-cell genomic approaches and follow-up functional assays is critical to discern the technical and biological contribution of noise in hematopoietic heterogeneity, to identify rare gene expression states, and to uncover functionally distinct subpopulations within hematopoiesis.
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