Immunoglobulin E (IgE)-mediated allergy against cow's milk protein fractions such as whey
is one of the most common food-related allergic disorders of early childhood. Histone
acetylation is an important epigenetic mechanism, shown to be involved in the pathogenesis
of allergies. However, its role in food allergy remains unknown. IgE-mediated cow's milk
allergy was successfully induced in a mouse model, as demonstrated by acute allergic
symptoms, whey-specific IgE in serum, and the activation of mast cells upon a challenge …