Decreased neural response for facial emotion processing in subjects with high genetic load for schizophrenia
Progress in neuro-psychopharmacology and biological psychiatry, 2016•Elsevier
Background Patients with schizophrenia show impairment in facial emotion processing
which is essential for successful social cognition. Using a functional magnetic resonance
imaging (fMRI), this study aimed to investigate the implicit facial emotion recognition
processing in participants with high genetic load for schizophrenia (GHR) as a possible trait
marker of developing schizophrenia. Methods Block design fMRI of implicit facial emotion
processing was used in 20 participants with GHR aged 16–35, and 17 age, sex, and …
which is essential for successful social cognition. Using a functional magnetic resonance
imaging (fMRI), this study aimed to investigate the implicit facial emotion recognition
processing in participants with high genetic load for schizophrenia (GHR) as a possible trait
marker of developing schizophrenia. Methods Block design fMRI of implicit facial emotion
processing was used in 20 participants with GHR aged 16–35, and 17 age, sex, and …
Background
Patients with schizophrenia show impairment in facial emotion processing which is essential for successful social cognition. Using a functional magnetic resonance imaging (fMRI), this study aimed to investigate the implicit facial emotion recognition processing in participants with high genetic load for schizophrenia (GHR) as a possible trait marker of developing schizophrenia.
Methods
Block design fMRI of implicit facial emotion processing was used in 20 participants with GHR aged 16–35, and 17 age, sex, and education year-matched healthy controls (HC). During the facial emotional processing for fearful, happy, and neutral face stimuli, participants were asked to explicitly determine the gender per stimuli.
Results
Occipito-temporo-limbic area in fearful face condition and involvement of broader region including prefrontal cortex in neutral face condition revealed significant attenuation of BOLD signal activation in GHR compared to HC. The GHR demonstrated less activity in right amygdala during fearful and neutral face condition.
Conclusion
The study presented that GHR displayed abnormal brain activity in occipito-temporo-limbic-frontal network implicated in facial emotion processing. It indicates that abnormal facial emotion processing may be influenced by a genetic factor and could be a trait marker in schizophrenia.
Elsevier
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