we report natural selection signatures in the Japanese population using 2234 high-depth
whole-genome sequence (WGS) data (25.9×). Using rare singletons, we identify signals of
very recent selection for the past 2000–3000 years in multiple loci (ADH cluster, MHC
region, BRAP-ALDH2, SERHL2). In large-scale genome-wide association study (GWAS)
dataset (n= 171,176), variants with selection signatures show enrichment in heterogeneity of …