[HTML][HTML] Deletion of Irf3 and Irf7 genes in mice results in altered interferon pathway activation and granulocyte-dominated inflammatory responses to influenza A …
B Hatesuer, HTT Hoang, P Riese, S Trittel… - Journal of innate …, 2017 - karger.com
The interferon (IFN) pathway plays an essential role in the innate immune response
following viral infections and subsequent shaping of adaptive immunity. Infections with
influenza A viruses (IAV) activate the IFN pathway after the recognition of pathogen-specific
molecular patterns by respective pattern recognition receptors. The IFN regulatory factors
IRF3 and IRF7 are key players in the regulation of type I and III IFN genes. In this study, we
analyzed the role of IRF3 and IRF7 for the host response to IAV infections in Irf3-/-, Irf7 …
following viral infections and subsequent shaping of adaptive immunity. Infections with
influenza A viruses (IAV) activate the IFN pathway after the recognition of pathogen-specific
molecular patterns by respective pattern recognition receptors. The IFN regulatory factors
IRF3 and IRF7 are key players in the regulation of type I and III IFN genes. In this study, we
analyzed the role of IRF3 and IRF7 for the host response to IAV infections in Irf3-/-, Irf7 …