Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation
BH Shah, JW Soh, KJ Catt - Journal of Biological Chemistry, 2003 - ASBMB
The hypothalamic decapeptide, gonadotropin-releasing hormone (GnRH), utilizes multiple
signaling pathways to activate extracellularly regulated mitogen-activated protein kinases
(ERK1/2) in normal and immortalized pituitary gonadotrophs and transfected cells
expressing the GnRH receptor. In immortalized hypothalamic GnRH neurons (GT1–7 cells),
which also express GnRH receptors, GnRH, epidermal growth factor (EGF), and phorbol 12-
myristate 13-acetate (PMA) caused marked phosphorylation of ERK1/2. This action of GnRH …
signaling pathways to activate extracellularly regulated mitogen-activated protein kinases
(ERK1/2) in normal and immortalized pituitary gonadotrophs and transfected cells
expressing the GnRH receptor. In immortalized hypothalamic GnRH neurons (GT1–7 cells),
which also express GnRH receptors, GnRH, epidermal growth factor (EGF), and phorbol 12-
myristate 13-acetate (PMA) caused marked phosphorylation of ERK1/2. This action of GnRH …
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