Design, synthesis, antimicrobial evaluation, and molecular docking of novel chiral urea/thiourea derivatives bearing indole, benzimidazole, and benzothiazole …
Urea/thiourea derivatives with heteroaromatic scaffolds such as indole, benzimidazole, and
benzothiazole were designed, synthesized, and evaluated for their potential antimicrobial
activity in vitro assays to establish against B. cereus, S. aureus, E. coli, and P. aeruginosa.
Our results indicate that compounds are only active in gram-positive bacteria. Molecular
docking studies were carried out for the most efficient compounds to understand the
interactions with proteins involved in peptidoglycan synthesis. ADME calculations indicate …
benzothiazole were designed, synthesized, and evaluated for their potential antimicrobial
activity in vitro assays to establish against B. cereus, S. aureus, E. coli, and P. aeruginosa.
Our results indicate that compounds are only active in gram-positive bacteria. Molecular
docking studies were carried out for the most efficient compounds to understand the
interactions with proteins involved in peptidoglycan synthesis. ADME calculations indicate …
以上显示的是最相近的搜索结果。 查看全部搜索结果