[HTML][HTML] Design, synthesis, molecular modeling, in silico ADME studies and anti-HIV-1 assay of new diazocoumarin derivatives
ZA Livani, M Safakish, Z Hajimahdi… - Iranian Journal of …, 2018 - ncbi.nlm.nih.gov
ZA Livani, M Safakish, Z Hajimahdi, S Soleymani, R Zabihollahi, MR Aghasadeghi, E Alipour…
Iranian Journal of Pharmaceutical Research: IJPR, 2018•ncbi.nlm.nih.gov… In vitro anti-HIV and cytotoxicity assays Anti-HIV-1 activity of synthesized compounds was
evaluated in single cycle replication assay which was evaluated in our laboratory and
reported previously (32-35). In this assay, the single-cycle replicable HIV NL4-3 virions (200
ng p24) were inoculated concurrently with compounds in different concentrations to the
Hela cells. The inhibition rate (%) of p24 expression was measured by capture …
evaluated in single cycle replication assay which was evaluated in our laboratory and
reported previously (32-35). In this assay, the single-cycle replicable HIV NL4-3 virions (200
ng p24) were inoculated concurrently with compounds in different concentrations to the
Hela cells. The inhibition rate (%) of p24 expression was measured by capture …
Design, Synthesis, Molecular Modeling, In Silico ADME Studies and Anti-HIV-1 Assay of New Diazocoumarin Derivatives
ncbi.nlm.nih.gov
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