Design, synthesis and bio-evaluation of C-1 alkylated tetrahydro-β-carboline derivatives as novel antifungal lead compounds
The field of antifungal agent has become static and development of resistance by the
pathogen as well as limited clinical efficacy of marketed drugs demand the constant
development of new antifungals. The presence of hydrocarbon chain of specific length
linked with various different heterocycles was found to be an important structural feature in
various antifungal lead compounds. Based on the prominent antimicrobial activity of β-
carboline derivatives, a set of C1 alkylated tetrahydro-β-carboline derivatives were proposed …
pathogen as well as limited clinical efficacy of marketed drugs demand the constant
development of new antifungals. The presence of hydrocarbon chain of specific length
linked with various different heterocycles was found to be an important structural feature in
various antifungal lead compounds. Based on the prominent antimicrobial activity of β-
carboline derivatives, a set of C1 alkylated tetrahydro-β-carboline derivatives were proposed …
Design, synthesis and bio-evaluation of C-1 alkylated tetrahydro-β-carboline derivatives as novel antifungal lead compounds.
RS Rahul Singh, AJ Aanchal Jaisingh, IK Maurya… - 2020 - cabidigitallibrary.org
The field of antifungal agent has become static and development of resistance by the
pathogen as well as limited clinical efficacy of marketed drugs demand the constant
development of new antifungals. The presence of hydrocarbon chain of specific length
linked with various different heterocycles was found to be an important structural feature in
various antifungal lead compounds. Based on the prominent antimicrobial activity of β-
carboline derivatives, a set of C1 alkylated tetrahydro-β-carboline derivatives were proposed …
pathogen as well as limited clinical efficacy of marketed drugs demand the constant
development of new antifungals. The presence of hydrocarbon chain of specific length
linked with various different heterocycles was found to be an important structural feature in
various antifungal lead compounds. Based on the prominent antimicrobial activity of β-
carboline derivatives, a set of C1 alkylated tetrahydro-β-carboline derivatives were proposed …
以上显示的是最相近的搜索结果。 查看全部搜索结果