[HTML][HTML] Design, synthesis and biological evaluation of new 1, 4-dihydropyridine (DHP) derivatives as selective cyclooxygenase-2 inhibitors
I Sabakhi, V Topuzyan, Z Hajimahdi… - Iranian Journal of …, 2015 - ncbi.nlm.nih.gov
Iranian Journal of Pharmaceutical Research: IJPR, 2015•ncbi.nlm.nih.gov
… In this study novel 1, 4-dihydropyridine derivatives were prepared according to Hantzsch
reaction and evaluated for in vitro COX-1/COX-2 isozyme inhibition. We also performed
docking studies to determine the orientation of the synthesized compounds in the COX-2
active site which led to the better understanding of the structure-activity relationship in
designed COX-2 inhibitors. … In conclusion, new 1, 4-dihydropyridine derivatives were
synthesized and evaluated for COX-1/COX-2 inhibition. Among them, compound 5e …
reaction and evaluated for in vitro COX-1/COX-2 isozyme inhibition. We also performed
docking studies to determine the orientation of the synthesized compounds in the COX-2
active site which led to the better understanding of the structure-activity relationship in
designed COX-2 inhibitors. … In conclusion, new 1, 4-dihydropyridine derivatives were
synthesized and evaluated for COX-1/COX-2 inhibition. Among them, compound 5e …
Design, Synthesis and Biological Evaluation of New 1, 4-Dihydropyridine (DHP) Derivatives as Selective Cyclooxygenase-2 Inhibitors
ncbi.nlm.nih.gov
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