Design and Synthesis of a Cyclic Double Mutant Peptide (cyclo(87−99)[A91,A96]MBP87−99) Induces Altered Responses in Mice after Conjugation to Mannan …
Journal of medicinal chemistry, 2009•ACS Publications
Altered peptide ligands that alter immune responses are a promising approach to the
immunotherapy of multiple sclerosis. Cyclic peptides are of interest because the limited
stability of linear peptides restricts their use in vivo. We designed and synthesized a cyclic
double mutant peptide from MBP87− 99-[cyclo (87− 99)[A91, A96] MBP87− 99].
Immunization of mice, in CFA reduced Th1 responses. However, when conjugated to
reduced mannan, a significant further reduction of Th1 responses and moderate Th2 …
immunotherapy of multiple sclerosis. Cyclic peptides are of interest because the limited
stability of linear peptides restricts their use in vivo. We designed and synthesized a cyclic
double mutant peptide from MBP87− 99-[cyclo (87− 99)[A91, A96] MBP87− 99].
Immunization of mice, in CFA reduced Th1 responses. However, when conjugated to
reduced mannan, a significant further reduction of Th1 responses and moderate Th2 …
Altered peptide ligands that alter immune responses are a promising approach to the immunotherapy of multiple sclerosis. Cyclic peptides are of interest because the limited stability of linear peptides restricts their use in vivo. We designed and synthesized a cyclic double mutant peptide from MBP87−99-[cyclo(87−99)[A91,A96]MBP87−99]. Immunization of mice, in CFA reduced Th1 responses. However, when conjugated to reduced mannan, a significant further reduction of Th1 responses and moderate Th2 responses were induced.
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