The present article describes novel highly nonlinear photonic crystal fibers (HN-PCFs) with flattened chromatic dispersion and low confinement losses. The proposed design has been simulated based on the finite-difference method with anisotropic perfectly matched layers absorbing boundary condition. It is proved that the design novel HN-PCFs is obtained a nonlinear coefficient greater than 45W⁻¹km⁻¹ and low dispersion slope −0.009ps/(nm².km) at 1.55μm wavelength. In addition, results from numerical simulation show that the ultra-flattened dispersion of 0±0.65ps/(nm.km) can be obtained in a 1.36–1.62μm wavelength range with confinement losses lower than 10⁻⁷dB/m in the same wavelength range. Another advantage of the proposed HN-PCFs is that it possessed modest number of design parameters.