Design of anticoagulant surfaces based on cellulose nanocrystals
HMA Ehmann, T Mohan, M Koshanskaya… - Chemical …, 2014 - pubs.rsc.org
HMA Ehmann, T Mohan, M Koshanskaya, S Scheicher, D Breitwieser, V Ribitsch…
Chemical Communications, 2014•pubs.rsc.orgThe anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs)
prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of
negatively charged sulfate groups, which mimic the naturally occurring anticoagulant
heparin in terms of charge density. It is demonstrated that CNC decorated surfaces
significantly enhance the coagulation times of blood plasma and whole blood as proven by
QCM-D and simple clotting tests.
prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of
negatively charged sulfate groups, which mimic the naturally occurring anticoagulant
heparin in terms of charge density. It is demonstrated that CNC decorated surfaces
significantly enhance the coagulation times of blood plasma and whole blood as proven by
QCM-D and simple clotting tests.
The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.
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