Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo
TrAC Trends in Analytical Chemistry, 2008•Elsevier
Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly (o-
phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that
make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This
review highlights PEC sensitivity and selectivity parameters, which allow development of the
basic design in a systematic way in order to improve their performance and to diversify the
analyte range of these novel probes of brain function.
phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that
make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This
review highlights PEC sensitivity and selectivity parameters, which allow development of the
basic design in a systematic way in order to improve their performance and to diversify the
analyte range of these novel probes of brain function.
Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly(o-phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This review highlights PEC sensitivity and selectivity parameters, which allow development of the basic design in a systematic way in order to improve their performance and to diversify the analyte range of these novel probes of brain function.
Elsevier
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