Determination of Ochratoxin-A in the brain microdialysates and plasma of awake, freely moving rats using ultra high performance liquid chromatography fluorescence …
In this study, a simple, efficient and rapid Ultra High Performance Liquid Chromatography
method with fluorescence detection (UHPLC-FLD) has been developed and validated for
the determination of Ochratoxin-A (OTA) in rat brain microdialysates and plasma samples.
Six adult male wistar rats were used in the study and a single dose (5 mg/kg bw) of OTA was
given by intraperitoneal (ip) injection. Rat blood and microdialysate samples were collected
simultaneously after ip injection in awake freely moving rats, over a twelve-hour period. An …
method with fluorescence detection (UHPLC-FLD) has been developed and validated for
the determination of Ochratoxin-A (OTA) in rat brain microdialysates and plasma samples.
Six adult male wistar rats were used in the study and a single dose (5 mg/kg bw) of OTA was
given by intraperitoneal (ip) injection. Rat blood and microdialysate samples were collected
simultaneously after ip injection in awake freely moving rats, over a twelve-hour period. An …
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