Development and validation of simultaneous UV spectrophotometric method for the determination of Levofloxacin and Ambroxol in tablets
T Patil, Y Pore - Journal of the Korean Chemical Society, 2008 - koreascience.kr
T Patil, Y Pore
Journal of the Korean Chemical Society, 2008•koreascience.krLevofloxacin hemihydrate (LFX)(Fig. 1A) chemically,[(-)(s)-9-fluro-2, 3-dihydro-3-methyl-10-
(4-methyl-1-piperazinyl-7-oxo-7H-pyrido [1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic acid is
an optically L-isomer of ofloxacin. 1 It is a broad spectrum fluoroquinolone class of
antibacterial agent and effective against many gram positive and gram negative bacteria. 2,
3 It is a potent inhibitor of bacterial DNA gyrase enzyme (topoisomerase II & IV), which is
necessary for negative supercoiling of DNA prior to replication. 4Ambroxol hydrochloride …
(4-methyl-1-piperazinyl-7-oxo-7H-pyrido [1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic acid is
an optically L-isomer of ofloxacin. 1 It is a broad spectrum fluoroquinolone class of
antibacterial agent and effective against many gram positive and gram negative bacteria. 2,
3 It is a potent inhibitor of bacterial DNA gyrase enzyme (topoisomerase II & IV), which is
necessary for negative supercoiling of DNA prior to replication. 4Ambroxol hydrochloride …
Levofloxacin hemihydrate (LFX)(Fig. 1A) chemically,[(-)(s)-9-fluro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl-7-oxo-7H-pyrido [1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic acid is an optically L-isomer of ofloxacin. 1 It is a broad spectrum fluoroquinolone class of antibacterial agent and effective against many gram positive and gram negative bacteria. 2, 3 It is a potent inhibitor of bacterial DNA gyrase enzyme (topoisomerase II & IV), which is necessary for negative supercoiling of DNA prior to replication. 4
Ambroxol hydrochloride (ABX)(Fig. 1B) chemically, 4-[(2-amino-3, 5-dibromophenyl)-methyl]-amino] cyclohexanol hydrochloride is a mucolytic expectorant and used to reduce the viscosity of mucous secretions. 5
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