Results Erythema and dry desquamation (grade 1), moist desquamation (grade 3), and
ulceration (grade 4) appeared 4, 6 and 9 weeks after irradiation, respectively. Fields
receiving 15 Gy healed without ulceration while irradiation≥ 50 Gy resulted in necrosis. In
the spectrophotometer analysis, mean values of erythema indices for the 15 Gy fields
showed early and gradual increase from 0.8 at 1 week to a peak of 2.1 at 9 weeks, and a
decrease to 1.8 at 12 weeks post-irradiation. Melanin indices began increasing sharply from …

A porcine skin model was developed to characterize the dose-dependent response to high-
dose radiation. The dorsal skin of a mini pig was divided into four paraspinal sections, with
11 small irradiation fields (2 cm× 2 cm) in each section, and a single fraction of 15, 30, 50 or
75 Gy was delivered to each section using a 6 MeV electron beam. A spectrophotometer
measured gross skin changes, and a biopsy for each radiation dose was performed in the
1st, 2nd, 4th, 6th and 9th weeks for histology, immunostaining with anti-CD31, and western …