Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies
LE Doepker, S Danon, E Harkins, DK Ralph, Z Yaffe… - Elife, 2021 - elifesciences.org
A prerequisite for the design of an HIV vaccine that elicits protective antibodies is
understanding the developmental pathways that result in desirable antibody features. The
development of antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) is
particularly relevant because such antibodies have been associated with HIV protection in
humans. We reconstructed the developmental pathways of six human HIV-specific ADCC
antibodies using longitudinal antibody sequencing data. Most of the inferred naive …
understanding the developmental pathways that result in desirable antibody features. The
development of antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) is
particularly relevant because such antibodies have been associated with HIV protection in
humans. We reconstructed the developmental pathways of six human HIV-specific ADCC
antibodies using longitudinal antibody sequencing data. Most of the inferred naive …
Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies.
W Jaoko, LE Doepker, S Danon, E Harkins, ME Garrett… - 2021 - erepository.uonbi.ac.ke
A prerequisite for the design of an HIV vaccine that elicits protective antibodies is
understanding the developmental pathways that result in desirable antibody features. The
development of antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) is
particularly relevant because such antibodies have been associated with HIV protection in
humans. We reconstructed the developmental pathways of six human HIV-specific ADCC
antibodies using longitudinal antibody sequencing data. Most of the inferred naive …
understanding the developmental pathways that result in desirable antibody features. The
development of antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) is
particularly relevant because such antibodies have been associated with HIV protection in
humans. We reconstructed the developmental pathways of six human HIV-specific ADCC
antibodies using longitudinal antibody sequencing data. Most of the inferred naive …
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