Dietary fiber effects in chronic kidney disease: a systematic review and meta-analysis of controlled feeding trials
L Chiavaroli, A Mirrahimi, JL Sievenpiper… - European journal of …, 2015 - nature.com
European journal of clinical nutrition, 2015•nature.com
Results: A total of 14 trials involving 143 participants met the eligibility criteria. Dietary fiber
supplementation significantly reduced serum urea and creatinine levels in the primary
pooled analyses (MD,− 1.76 mmol/l (95% CI,− 3.00,− 0.51), P< 0.01 and MD,− 22.83 mmol/l
(95% CI,− 42.63,− 3.02), P= 0.02, respectively) with significant evidence of interstudy
heterogeneity only in the analysis of serum urea. Conclusions: This is the first study to
summarize the potential beneficial effects of dietary fiber in the CKD population …
supplementation significantly reduced serum urea and creatinine levels in the primary
pooled analyses (MD,− 1.76 mmol/l (95% CI,− 3.00,− 0.51), P< 0.01 and MD,− 22.83 mmol/l
(95% CI,− 42.63,− 3.02), P= 0.02, respectively) with significant evidence of interstudy
heterogeneity only in the analysis of serum urea. Conclusions: This is the first study to
summarize the potential beneficial effects of dietary fiber in the CKD population …
Results:
A total of 14 trials involving 143 participants met the eligibility criteria. Dietary fiber supplementation significantly reduced serum urea and creatinine levels in the primary pooled analyses (MD,− 1.76 mmol/l (95% CI,− 3.00,− 0.51), P< 0.01 and MD,− 22.83 mmol/l (95% CI,− 42.63,− 3.02), P= 0.02, respectively) with significant evidence of interstudy heterogeneity only in the analysis of serum urea.
Conclusions:
This is the first study to summarize the potential beneficial effects of dietary fiber in the CKD population demonstrating a reduction in serum urea and creatinine, as well as highlighting the lack of clinical trials on harder end points. Larger, longer, higher-quality clinical trials measuring a greater variety of uremic toxins in CKD are required (NCT01844882).
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