Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain
FCS Eng, A Barsalou, N Akutsu, I Mercier… - Journal of Biological …, 1998 - ASBMB
We have analyzed interaction of coactivators with the wild-type estrogen receptor α (ER),
HEG0, and a mutant, L536P-HEG0, which is constitutively active in several transiently
transfected cells and a HeLa line that stably propagates an estrogen-sensitive reporter
gene. Different classes of coactivators do not recognize the ER ligand binding domain (LBD)
in the same manner. Steroid receptor coactivator-1 (SRC-1), amplified in breast cancer-1
(AIB-1), transcriptional intermediary factor-1 (TIF-1), transcriptional intermediary factor-2 (TIF …
HEG0, and a mutant, L536P-HEG0, which is constitutively active in several transiently
transfected cells and a HeLa line that stably propagates an estrogen-sensitive reporter
gene. Different classes of coactivators do not recognize the ER ligand binding domain (LBD)
in the same manner. Steroid receptor coactivator-1 (SRC-1), amplified in breast cancer-1
(AIB-1), transcriptional intermediary factor-1 (TIF-1), transcriptional intermediary factor-2 (TIF …
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