[HTML][HTML] Different effects of oral contraceptives containing different progestogens on protein S and tissue factor pathway inhibitor
H Van Vliet, RM Bertina, AEA Dahm… - Journal of Thrombosis …, 2008 - Elsevier
Background: Oral contraceptives (OC) containing different types of progestogens induce
different sensitivities to activated protein C (APC) measured with the thrombin generation-
based APC-resistance test. These differences in APC resistance may be the biological
explanation for the differences in thrombotic risk of the various pills. The mechanistic basis of
APC resistance observed in OC users is unknown. Our objective was to study the effect of
OC on the two main determinants of the APC-resistance test, free protein S and free tissue …
different sensitivities to activated protein C (APC) measured with the thrombin generation-
based APC-resistance test. These differences in APC resistance may be the biological
explanation for the differences in thrombotic risk of the various pills. The mechanistic basis of
APC resistance observed in OC users is unknown. Our objective was to study the effect of
OC on the two main determinants of the APC-resistance test, free protein S and free tissue …
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