Eph receptor tyrosine kinases (RTK) comprise the largest family of tyrosine kinases encoded
in the human genome. 1, 2 Fourteen Eph receptors and eight ephrin ligands have been
identified to date and these molecules are increasingly understood to play important roles in
disease and development. 3–5 Eph receptor family members share structural and functional
similarities. Their extracellular regions include an N-terminal ligand binding domain, 6, 7 a
cysteine-rich motif, and two fibronectin-like repeats. Also, Eph receptors can be …