Differential regulation of human PlGF gene expression in trophoblast and nontrophoblast cells by oxygen tension
OBJECTIVE: To determine the mechanism for differential effects of low oxygen tension on
human PlGF gene transcription in trophoblast and nontrophoblast cells. STUDY DESIGN:
Human PlGF reporter clones and real-time RT-PCR were used to compare the effects of
hypoxia on gene transcription in human trophoblast and nontrophoblast cell lines.
Overexpression of HIF-1α, inhibition of HIF-1 function and biochemical assessments of HIF-1
co-factor interactions were used to characterize hypoxia response mechanisms regulating …
human PlGF gene transcription in trophoblast and nontrophoblast cells. STUDY DESIGN:
Human PlGF reporter clones and real-time RT-PCR were used to compare the effects of
hypoxia on gene transcription in human trophoblast and nontrophoblast cell lines.
Overexpression of HIF-1α, inhibition of HIF-1 function and biochemical assessments of HIF-1
co-factor interactions were used to characterize hypoxia response mechanisms regulating …
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