Differentiation of putative hepatic stem cells derived from adult rats into mature hepatocytes in the presence of epidermal growth factor and hepatocyte growth factor
ZP He, WQ Tan, YF Tang, MF Feng - Differentiation, 2003 - Elsevier
Oval cells, putative hepatic stem cells, can differentiate into a wide range of cell types
including hepatocytes, bile epithelial cells, pancreatic cells and intestinal epithelial cells. In
this study, we used different growth factor combinations to induce oval cells to differentiate
into mature hepatocytes. We isolated and purified oval cells utilizing selective enzymatic
digestion and density gradient centrifugation. Oval cells were identified by their
morphological characteristics and the strong expressions of OV-6, albumin, cytokeratin (CK) …
including hepatocytes, bile epithelial cells, pancreatic cells and intestinal epithelial cells. In
this study, we used different growth factor combinations to induce oval cells to differentiate
into mature hepatocytes. We isolated and purified oval cells utilizing selective enzymatic
digestion and density gradient centrifugation. Oval cells were identified by their
morphological characteristics and the strong expressions of OV-6, albumin, cytokeratin (CK) …
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