[引用][C] Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-delated adenovirus.
JF ENGEHARDT - Nature Genet., 1993 - cir.nii.ac.jp
Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-delated
adenovirus. | CiNii Research … Direct gene transfer of human CFTR into human bronchial
epithelia of xenografts with E1-delated adenovirus. …
adenovirus. | CiNii Research … Direct gene transfer of human CFTR into human bronchial
epithelia of xenografts with E1-delated adenovirus. …
Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses
JF Engelhardt, Y Yang, LD Stratford-Perricaudet… - Nature Genetics, 1993 - nature.com
We describe the use of a human bronchial xenograft model for studying the efficiency and
biology of in vivo gene transfer into human bronchial epithelia with recombinant E1 deleted
adenoviruses. All cell types in the surface epithelium except basal cells efficiently expressed
the adenoviral transduced recombinant genes, lacZ and CFTR, for 3–5 weeks. Stable
transgene expression was associated with high level expression of the early adenoviral
gene, E2a, in a subset of transgene expressing cells and virtually undetectable expression …
biology of in vivo gene transfer into human bronchial epithelia with recombinant E1 deleted
adenoviruses. All cell types in the surface epithelium except basal cells efficiently expressed
the adenoviral transduced recombinant genes, lacZ and CFTR, for 3–5 weeks. Stable
transgene expression was associated with high level expression of the early adenoviral
gene, E2a, in a subset of transgene expressing cells and virtually undetectable expression …
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