Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells
E Chiricozzi, MG Ciampa, G Brasile… - Journal of lipid …, 2015 - ASBMB
Lactosylceramide [LacCer; β-Gal-(1-4)-β-Glc-(1-1)-Cer] has been shown to contain very long
fatty acids that specifically modulate neutrophil properties. The interactions between LacCer
and proteins and their role in cell signaling processes were assessed by synthesizing two
molecular species of azide-photoactivable tritium-labeled LacCer having acyl chains of
different lengths. The lengths of the two acyl chains corresponded to those of a
short/medium and very long fatty acid, comparable to the lengths of stearic and lignoceric …
fatty acids that specifically modulate neutrophil properties. The interactions between LacCer
and proteins and their role in cell signaling processes were assessed by synthesizing two
molecular species of azide-photoactivable tritium-labeled LacCer having acyl chains of
different lengths. The lengths of the two acyl chains corresponded to those of a
short/medium and very long fatty acid, comparable to the lengths of stearic and lignoceric …
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