Improving interfacial thermal transport is crucial for heat dissipation in devices with interfaces, such as electronics, buildings, and solar panels. Here, we design a strategy by utilizing the water adsorption-desorption process in porous metal-organic frameworks (MOFs) to tune the interfacial heat transfer, which could benefit their potential in cooling or heat dissipation applications. We observe a changeable thermal conductance across the solid/porous MOF interfaces owing to the dense water channel formed by the adsorbed water molecules in MOFs. Our experimental and/or modeling results show that the interfacial thermal conductance of Au/Cu₃(BTC)₂, Au/Zr₆O₄(OH)₄(BDC)₆ and Au/MOF-505 heterointerfaces is increased up to 7.1, 1.7 and 3.1 folds by this strategy, respectively, where Cu₃(BTC)₂ is referred to as HKUST-1 and Zr₆O₄(OH)₄(BDC)₆ is referred to as UiO-66. Our molecular dynamics simulations further show that the surface tension of Au layer will cause the adsorbed water molecules in MOFs to gather at the interfacial region. The dense water channel formed at the interfacial region can activate the high-frequency lattice vibrations and act as an additional thermal pathway, and then enhance heat transfer across the interfaces significantly. Our findings revealed the underlying mechanisms for tailoring thermal transport at the solid/porous MOF heterointerfaces by water adsorbates, which could motivate and benefit the new cooling system design based on MOFs.