Direct visualization of specifically modified extracellular glycans in living animals
Modification patterns of heparan sulfate coordinate protein function in metazoans, yet in vivo
imaging of such non–genetically encoded structures has been impossible. Here we report a
transgenic method in Caenorhabditis elegans that allows direct live imaging of specific
heparan sulfate modification patterns. This experimental approach reveals a dynamic and
cell-specific heparan sulfate landscape and could in principle be adapted to visualize and
analyze any extracellular molecule in vivo.
imaging of such non–genetically encoded structures has been impossible. Here we report a
transgenic method in Caenorhabditis elegans that allows direct live imaging of specific
heparan sulfate modification patterns. This experimental approach reveals a dynamic and
cell-specific heparan sulfate landscape and could in principle be adapted to visualize and
analyze any extracellular molecule in vivo.
Abstract
Modification patterns of heparan sulfate coordinate protein function in metazoans, yet in vivo imaging of such non–genetically encoded structures has been impossible. Here we report a transgenic method in Caenorhabditis elegans that allows direct live imaging of specific heparan sulfate modification patterns. This experimental approach reveals a dynamic and cell-specific heparan sulfate landscape and could in principle be adapted to visualize and analyze any extracellular molecule in vivo.
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