Disclosing the interaction of carbonic anhydrase IX with cullin-associated NEDD8-dissociated protein 1 by molecular modeling and integrated binding measurements
M Buonanno, E Langella, N Zambrano… - ACS Chemical …, 2017 - ACS Publications
Human Carbonic Anhydrase (hCA) IX is a membrane-associated member of the CA enzyme
family, involved in solid tumor acidification. This enzyme is a marker of tumor hypoxia and a
prognostic factor for several human cancers. In a recent paper, we showed that CA IX
interacts with cullin-associated NEDD8-dissociated protein 1 (CAND1), a nuclear protein
involved in gene transcription and assembly of SCF ubiquitin ligase complexes. A functional
role for this interaction was also identified, since lower CA IX levels were observed in cells …
family, involved in solid tumor acidification. This enzyme is a marker of tumor hypoxia and a
prognostic factor for several human cancers. In a recent paper, we showed that CA IX
interacts with cullin-associated NEDD8-dissociated protein 1 (CAND1), a nuclear protein
involved in gene transcription and assembly of SCF ubiquitin ligase complexes. A functional
role for this interaction was also identified, since lower CA IX levels were observed in cells …
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