Discovery of polymethoxyflavones from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors
Inhibition of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) has emerged as a
prime target in Alzheimer's disease research because BACE1 is the rate-limiting enzyme
involved in the abnormal production of β-amyloid peptides. In the course of exploring natural
BACE1 inhibitors, the present study focused on the major polymethoxyflavones from
Kaempferia parviflora: 5, 7-dimethoxyflavone (DMF), 5, 7, 4′-trimethoxyflavone (TMF), and
3, 5, 7, 3′, 4′-pentamethoxyflavone (PMF). All polymethoxyflavones exhibited strong …
prime target in Alzheimer's disease research because BACE1 is the rate-limiting enzyme
involved in the abnormal production of β-amyloid peptides. In the course of exploring natural
BACE1 inhibitors, the present study focused on the major polymethoxyflavones from
Kaempferia parviflora: 5, 7-dimethoxyflavone (DMF), 5, 7, 4′-trimethoxyflavone (TMF), and
3, 5, 7, 3′, 4′-pentamethoxyflavone (PMF). All polymethoxyflavones exhibited strong …
Discovery of polymethoxyflavones from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors.
YKJ Youn KumJu, LJH Lee JinHyuk, HCT Ho ChiTang… - 2016 - cabidigitallibrary.org
Inhibition of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) has emerged as a
prime target in Alzheimer's disease research because BACE1 is the rate-limiting enzyme
involved in the abnormal production of β-amyloid peptides. In the course of exploring natural
BACE1 inhibitors, the present study focused on the major polymethoxyflavones from
Kaempferia parviflora: 5, 7-dimethoxyflavone (DMF), 5, 7, 4′-trimethoxyflavone (TMF), and
3, 5, 7, 3′, 4′-pentamethoxyflavone (PMF). All polymethoxyflavones exhibited strong …
prime target in Alzheimer's disease research because BACE1 is the rate-limiting enzyme
involved in the abnormal production of β-amyloid peptides. In the course of exploring natural
BACE1 inhibitors, the present study focused on the major polymethoxyflavones from
Kaempferia parviflora: 5, 7-dimethoxyflavone (DMF), 5, 7, 4′-trimethoxyflavone (TMF), and
3, 5, 7, 3′, 4′-pentamethoxyflavone (PMF). All polymethoxyflavones exhibited strong …