Disorder, oscillatory dynamics and state switching: the role of c-Myc
In this paper, using the intrinsically disordered oncoprotein Myc as an example, we present
a mathematical model to help explain how protein oscillatory dynamics can influence state
switching. Earlier studies have demonstrated that, while Myc overexpression can facilitate
state switching and transform a normal cell into a cancer phenotype, its downregulation can
reverse state-switching. A fundamental aspect of the model is that a Myc threshold
determines cell fate in cells expressing p53. We demonstrate that a non-cooperative positive …
a mathematical model to help explain how protein oscillatory dynamics can influence state
switching. Earlier studies have demonstrated that, while Myc overexpression can facilitate
state switching and transform a normal cell into a cancer phenotype, its downregulation can
reverse state-switching. A fundamental aspect of the model is that a Myc threshold
determines cell fate in cells expressing p53. We demonstrate that a non-cooperative positive …
Disorder, oscillatory dynamics and state switching: the role of c-Myc
Z Fox, A Singh, N RANGARAJAN, P Kulkarni… - 2015 - dr.iiserpune.ac.in
In this paper, using the intrinsically disordered oncoprotein Myc as an example, we present
a mathematical model to help explain how protein oscillatory dynamics can influence state
switching. Earlier studies have demonstrated that, while Myc overexpression can facilitate
state switching and transform a normal cell into a cancer phenotype, its downregulation can
reverse state-switching. A fundamental aspect of the model is that a Myc threshold
determines cell fate in cells expressing p53. We demonstrate that a non-cooperative positive …
a mathematical model to help explain how protein oscillatory dynamics can influence state
switching. Earlier studies have demonstrated that, while Myc overexpression can facilitate
state switching and transform a normal cell into a cancer phenotype, its downregulation can
reverse state-switching. A fundamental aspect of the model is that a Myc threshold
determines cell fate in cells expressing p53. We demonstrate that a non-cooperative positive …
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