… mechanotransduction signaling as a critical driver of fibrosis after … to reduce scar contracture,
promote regenerative dermal remodeling, encourage early engraftment, and improve graft …

… fibrosis, with the formation of hypertrophic scars (HTS) that severely compromise physiologic
skin … structures is split-thickness skin grafting (STSG); however, skin grafts often result in …

… matory and mechanotransduction signaling pathways in standard split thickness skin grafts.
… , we substantially promoted engraftment, reduced contracture, mitigated scar formation, …

… target to reduce scarring and promote skin regeneration. In … therapeutic option to prevent
wound fibrosis and contracture. … model of autologous split-thickness skin grafting (STSG) and …

… to fibroblast mechanotransduction in the skin are still … split-thickness skin-grafting (STSG),
a common intervention for deep tissue injuries that is also associated with causing contractures …

… to reduce the burden of insulin injection-induced skin fibrosis. … patch (which did not disturb
the attachment or placement of … tissue mechanics and mechanotransduction signaling across …

… from scleroderma and skin grafting. The development of … disruption of mechanotransduction
to inhibit fibrosis. Given … in significant stimulation of collagen lattice contraction, in a manner …

… mechanotransduction. … of fibrosis and scarring as a primary outcome, this paper takes the
informed and interesting approach of also applying the principles of mechanotransduction to …

… production to effect wound contraction and dermal thickening (18). … by either reducing
mechanotransduction or promoting … and reducing scarring in patients receiving split-skin grafts (…

… healing by inhibiting the mechanotransduction of YAP. … and contractures was greatly reduced.
This shows that dHACM is a safe, feasible and superior alternative to layered skin grafting. …