Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflow
S Chowdhury, A Gomez Toledo, E Hjortswang… - bioRxiv, 2023 - biorxiv.org
Most individuals maintain circulating antibodies against various pathogenic bacteria as a
consequence of previous exposures. However, it remains unclear to what extent these
antibodies contribute to host protection. This knowledge gap is linked to the need for better
methods to characterize antimicrobial polyclonal antibodies, including their antigen and
epitope repertoires, subclass distribution, glycosylation status, and effector functions. Here,
we showcase a generic mass spectrometry-based strategy that couples systems …
consequence of previous exposures. However, it remains unclear to what extent these
antibodies contribute to host protection. This knowledge gap is linked to the need for better
methods to characterize antimicrobial polyclonal antibodies, including their antigen and
epitope repertoires, subclass distribution, glycosylation status, and effector functions. Here,
we showcase a generic mass spectrometry-based strategy that couples systems …
Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflow
J Malmstrom, S Chowdhury, E Hjortswang… - 2023 - europepmc.org
Most individuals maintain circulating antibodies against various pathogenic bacteria as a
consequence of previous exposures. However, it remains unclear to what extent these
antibodies contribute to host protection. This knowledge gap is linked to the need for better
methods to characterize antimicrobial polyclonal antibodies, including their antigen and
epitope repertoires, subclass distribution, glycosylation status, and effector functions. Here,
we showcase a generic mass spectrometry-based strategy that couples systems …
consequence of previous exposures. However, it remains unclear to what extent these
antibodies contribute to host protection. This knowledge gap is linked to the need for better
methods to characterize antimicrobial polyclonal antibodies, including their antigen and
epitope repertoires, subclass distribution, glycosylation status, and effector functions. Here,
we showcase a generic mass spectrometry-based strategy that couples systems …
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