Distal colonic K+ secretion occurs via BK channels
M Sausbier, JE Matos, U Sausbier… - Journal of the …, 2006 - journals.lww.com
K+ secretion in the kidney and distal colon is a main determinant of K+ homeostasis. This
study investigated the identity of the relevant luminal secretory K+ ion channel in distal
colon. An Ussing chamber was used to measure ion transport in the recently generated BK
channel–deficient (BK−/−) mice. BK−/− mice display a significant colonic epithelial
phenotype with (1) lack of Ba 2+-sensitive resting K+ secretion,(2) absence of K+ secretion
stimulated by luminal P2Y 2 and P2Y 4 receptors,(3) absence of luminal Ca 2+ ionophore …
study investigated the identity of the relevant luminal secretory K+ ion channel in distal
colon. An Ussing chamber was used to measure ion transport in the recently generated BK
channel–deficient (BK−/−) mice. BK−/− mice display a significant colonic epithelial
phenotype with (1) lack of Ba 2+-sensitive resting K+ secretion,(2) absence of K+ secretion
stimulated by luminal P2Y 2 and P2Y 4 receptors,(3) absence of luminal Ca 2+ ionophore …
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