Background. The molecular mechanism of small-for-size graft injury remains unclear. The
aim of this study is to investigate the gene expression pattern of acute phase response in
relation to graft size in a rat-liver transplantation model. Methods. A rat orthotopic liver
transplantation model using 30%, 50%, and whole grafts was used. The graft survival rates
and liver morphology were compared among the three groups. Two transcription factors,
nuclear factor (NF)-κB (p65) and early growth response (Egr-1), and their downstream …

BACKGROUND: The understanding of graft injury in relation to graft size at cellular level is
important to develop new strategies to rescue marginal graft. The aim of this study was to
investigate the intragraft response in relation to graft size in a rat liver transplantation model.
MATERIALS AND METHODS: A rat orthotopic liver transplantation model using different
sized grafts (100%, 50% and 30% of recipient rat liver) was applied. The 7-day graft survival
rates were compared among the three groups. Two transcription factors, namely, NK-kB and …