Distinguishing mode of action of compounds inducing craniofacial malformations in zebrafish embryos to support dose-response modeling in combined exposures
HJ Heusinkveld, WG Schoonen… - Reproductive …, 2020 - Elsevier
Abstract Knowledge on mode-of-action (MOA) is required to understand toxicological effects
of compounds, notably in the context of risk assessment of mixtures. Such information is
generally scarce, and often complicated by the existence of multiple MOAs per compound.
Here, MOAs related to developmental craniofacial malformations were derived from
literature, and assembled in a MOA network. A selection of gene expression markers was
based on these MOAs. Next, these markers were verified by qPCR in zebrafish embryos …
of compounds, notably in the context of risk assessment of mixtures. Such information is
generally scarce, and often complicated by the existence of multiple MOAs per compound.
Here, MOAs related to developmental craniofacial malformations were derived from
literature, and assembled in a MOA network. A selection of gene expression markers was
based on these MOAs. Next, these markers were verified by qPCR in zebrafish embryos …
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