Blood group systems are determined early in intrauterine life, specific to the individual and therefore significant in management and identification. Seven hundred and ninety five volunteer students of the Abraka campus of Delta State University were analyzed in this 4-year retrospective study. Amongst ABO system, blood group O was most common followed by A, B and AB respectively. Rhesus positive was more common than Rhesus negative in the rhesus system. Gender had no significant effect on both blood group systems studied. In the combined ABO and Rhesus blood groups, O positive was most common followed by A positive, B positive, AB positive O negative and A negative respectively. This study documents ABO and Rhesus blood group distribution patterns amongst south southern Nigerians. Findings will be useful in maintaining a register of possible donors, for effective management of medical emergencies.