Background Helicobacter pylori (H. pylori) infection is known to be associated with a
spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence
markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA)
alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma
(GC) and duodenal ulcer (DU). Methods H. pylori infection established by both rapid urease
test and histology were studied. The cagA and vacA allelic status was determined by …

ABSTRACT BACKGROUND: Helicobacter pylori (H. pylori) is a major human pathogen that
is responsible for various gastroduodenal diseases. We investigated the prevalence of H.
pylori virulence markers in a region at high risk of gastric cancer. METHODS: One hundred
and sixteen H. pylori strains were isolated from patients with gastroduodenal diseases.
cagA, the cagA 3′ variable region, cagPAI genes, vacA, and dupA genotypes were
determined by PCR, and some amplicons of the cagA 3′ variable region, cagPAI genes …