Ceramide, a bioactive sphingolipid, is now at the forefront of cancer research. Classically,
ceramide is thought to induce death, growth inhibition, and senescence in cancer cells.
However, it is now clear that this simple picture of ceramide no longer holds true. Recent
studies suggest that there are diverse functions of endogenously generated ceramides,
which seem to be context dependent, regulated by subcellular/membrane localization and
presence/absence of direct targets of these lipid molecules. For example, different fatty-acid …