Diversity of long-chain toxins in Tityus zulianus and Tityus discrepans venoms (Scorpiones, Buthidae): molecular, immunological, and mass spectral analyses
In Venezuela, stings by Tityus zulianus scorpions produce cardiorespiratory arrest, whereas
envenoming by Tityus discrepans involves gastrointestinal/pancreatic complications,
suggesting structural and/or functional differences. We sought to compare their toxin
repertoires through immunological, molecular, and mass spectral analyses. First, in vivo
tests showed that neutralization of T. zulianus venom toxicity by the anti-T. discrepans
antivenom was not complete. To compare T. discrepans and T. zulianus long-chain (sodium …
envenoming by Tityus discrepans involves gastrointestinal/pancreatic complications,
suggesting structural and/or functional differences. We sought to compare their toxin
repertoires through immunological, molecular, and mass spectral analyses. First, in vivo
tests showed that neutralization of T. zulianus venom toxicity by the anti-T. discrepans
antivenom was not complete. To compare T. discrepans and T. zulianus long-chain (sodium …
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